profile-pic
Mike Lippincott
Computational Cell Biologist - PhD Candidate
University of Colorado Anschutz Medical Campus

About

My scientific vision is to bridge cell biology and computational science to advance fundamental biological knowledge to improve human health outcomes.


I am keen on understanding complex, dynamic cell death mechanisms via innovative, high throughput, high content microscopy and machine learning techniques. I am paving the way to model complex cell processes through temporal and 3D image data. It is with this approach that new interventions can be discovered to improve human health outcomes.

Live-cell timelapse
image-based profiling

3D image-based profiling of
NF1 patient derived organoids

3D Cell Painting representations of a NF1 patient derived organoid

3D Segmentation masks of NF1 patient derived organoids

Education

  • PhD - Computational Cell Biology, University of Colorado Anschutz Medical Campus

    Aurora, CO

    Aug. 2022 – May. 2027

  • BS - Biochemistry and Data Science, Maryville University of Saint Louis

    Saint Louis, MO

    Aug. 2017 – May. 2021

Research Experience

  • PhD Research - Computational Cell Biology

    University of Colorado, Gregory P. Way, PhD, Aurora, CO

    Aug. 2022 – Present

  • Post-baccalaureate Research Assistant - Genomics

    University of North Carolina at Chapel Hill, Shawn Ahmed, Chapel Hill, NC

    2021 – 2022

  • Research Assistant - Genome editing

    Centro de Technologia Canavieria, Saint Louis, MO

    2020 – 2021

  • Undergraduate Research Assistant - Quantitative spectroscopy

    Maryville University of Saint Louis, Thomas Spudich, PhD, Saint Louis, MO

    2019 – 2020

  • Undergraduate Research Assistant - Cell Biology

    Maryville University of Saint Louis, Stacy L. Donovan, PhD, Saint Louis, MO

    2018 – 2021

  • Research Internship - Biochemistry

    Elemental Enzymes, Saint Louis, MO

    2018 – 2019

Publications

Google Scholar: profile

  • Three-dimensional image-based profiling of NF1 patient-derived organoids uncovers heterogeneous drug response landscapes

    Michael J. Lippincott, Alberto Mendoza-Valderrey, Jenna Tomkinson, Dave Bunten, Sara Gosline, Alice Soragni, Gregory P. Way (2026)

  • High-content live-cell time-lapse imaging predicts cells about to die via apoptosis

    Michael J. Lippincott, Jenna Tomkinson, Ibrahim Bilem, Mahomi Suzuki, Akiko Nakde, Toshiaki Endou, Simon Mathien, Felix Lavoie-Perusse, Carla Basualto-Alarcón, Gregory P Way (2025)

    In Review at Cell Reports Methods: bioRxiv

  • Scalable data harmonization for single-cell image-based profiling with CytoTable

    Dave Bunten, Jenna Tomkinson, Erik Serrano, Michael J. Lippincott, Kenneth I. Brewer, Vince Rubinetti, Faisal Alquaddoomi, Gregory P. Way (2025)

    Available at: Patterns

  • Progress and new challenges in image-based profiling

    Erik Serrano, John Peters, Jesko Wagner, Rebecca E. Graham, Zhenghao Chen, Brian Feng, Gisele Miranda, Alexandr A. Kalinin, Loan Vulliard, Jenna Tomkinson, Cameron Mattson, Michael J. Lippincott, Ziqi Kang, Divya Sitani, Dave Bunten, Srijit Seal, Neil O. Carragher, Anne E. Carpenter, Shantanu Singh, Paula A. Marin Zapata, Juan C. Caicedo, Gregory P. Way (2025)

    Available at: Molecular Systems Biology

  • A quadratic paradigm describes the relationship between phenotype severity and variation

    Abigail Mumme-Monheit, Grace E. Gustafson, Colette A. Hopkins, Raisa Bailon-Zambrano, Juliana Sucharov, Michael J. Lippincott, Gregory P. Way, Kathryn L. Colborn, James T. Nichols (2025)

    Available at: Nature Communications

  • A morphology and secretome map of pyroptosis

    Michael J. Lippincott, Jenna Tomkinson, Dave Bunten, Milad Mohammadi, Johanna Kastl, Johannes Knop, Ralf Schwandner, Jiamin Huang, Grant Ongo, Nathaniel Robichaud, Milad Dagher, Masafumi Tsuboi, Carla Basualto-Alarcón, Gregory P. Way (2025)

    Available at: MBoC

  • Protein prediction models support widespread post-transcriptional regulation of protein abundance by interacting partners

    Srivastava H, Michael J. Lippincott, Currie J, Canfield R, Lam MPY, Lau E (2022)

    Available at: PLOS Computational Biology

  • Genetic and Epigenetic Inheritance at Telomeres

    Lister-Shimauchi EH, McCarthy B, Michael J. Lippincott, Ahmed S (2022)

    Available at: Epigenomes

Scientific Appointments

  • PhD student

    University of Colorado Anschutz Medical Campus, Aurora, CO

    Aug. 2022 – Present

  • Wellbeing and engagement committee, Department of Biomedical Informatics

    University of Colorado Anschutz Medical Campus, Aurora, CO

    Jul. 2024 – Jul. 2026

  • Journal Club Committee, Cell Biology, Stem Cells, and Development

    University of Colorado Anschutz Medical Campus, Aurora, CO

    2023 – 2025

  • Volunteer

    Clear Directions Mentoring, Aurora, CO

    2023 – Present

  • Cell Biology Graduate Teaching Assistant

    University of Colorado Anschutz Medical Campus, Aurora, CO

    2023 – Present

  • Research Assistant

    University of North Carolina at Chapel Hill, Chapel Hill, NC

    May. 2021 – May. 2022

  • Teaching Aid – Chemistry/Cell Biology

    Maryville University of Saint Louis, Saint Louis, MO

    2019 – 2021

  • Lab technician training manager

    Maryville University of Saint Louis, Saint Louis, MO

    2019 – 2021

  • Biology and Maths Tutor

    Maryville University of Saint Louis, Saint Louis, MO

    2017 – 2019

Presentations

Talks

  • Children's Tumor Foundation - NF Research Conference
    6/30/2026, Denver, CO

  • Cold Spring Harbor Laboratory - Cell modeling in space and time
    June 22, 2026, Cold Spring Harbor, NY

  • Michael Johnson Seminar Series, Maryville University
    Jan. 28, 2026, Saint Louis, MO

  • Neurofibramatosis Young Investigator's Forum
    Dec. 4, 2025, Baltimore, MD

  • Society of Biomolecular Imaging and Informatics
    Oct. 27, 2025, Boston, MA

  • Cell Biology, Stem Cells, and Development Retreat
    Oct. 24, 2025, Estes Park, CO

  • American Society for Cell Biology Cell Bio conference
    Dec. 3, 2024, San Diego, CA

  • Computational Systems for Integrative Genomics
    Jul. 18, 2024, New York, NY

  • Center for Health Artificial Intelligence Retreat
    Aug. 19, 2023, Aurora, CO

Posters

  • Society for Laboratory Automation and Screening (SLAS) Europe
    May 20, 2026, Vienna, Austria

  • Society of Biomolecular Imaging and Informatics
    Oct. 26, 2025, Boston, MA

  • Systems applications for cancer biology
    Feb. 10, 2025, Aurora, CO

  • Cell Biology, Stem Cells, and Development Retreat
    Oct. 18, 2024, Breckinridge, CO

  • Center for Health Artificial Intelligence Retreat
    Aug. 27, 2024, Denver, CO

  • American Society for Cell Biology Cell Bio conference
    Dec. 3, 2023, Boston, MA

  • Cell Biology, Stem Cells, and Development Retreat
    Oct. 13, 2023, Breckinridge, CO

Software Contributions

Skills

Python
R
SQL
Bash
Nextflow
HPC Orchestration (SLURM)
AWS
GCP
terraform
Singularity/Apptainer
Docker
Git
Pytorch
Scikit-learn
Pandas
NumPy
SciPy
Optuna
Seaborn
Matplotlib
ggoplot2
Plotly
dash
CellProfiler
napari
Fiji/ImageJ
Database Management
Statistical Analysis
Data Visualization
Data Wrangling
Data Mining
Computer Vision
ViTs
Graph-based Learning
Agentic AI