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Mike Lippincott
Computational Cell Biologist - PhD Candidate
University of Colorado Anschutz Medical Campus

About

My scientific vision is to bridge cell biology and computational science to advance fundamental biological knowledge to improve human health outcomes.


I am keen on understanding cell death mechanisms via innovated high throughput, high content microscopy and machine learning techniques. I am paving the way to model complex cell processes through time and 3D image data. It is with this approach that new interventions can be discovered to improve human health outcomes.

Live-cell timelapse
image-based profiling

3D image-based profiling of
NF1 patient derived organoids

3D Cell Painting representations of a NF1 patient derived organoid

3D Segmentation masks of NF1 patient derived organoids

Publications

  • Scalable data harmonization for single-cell image-based profiling with CytoTable

    Dave Bunten, Jenna Tomkinson, Erik Serrano, Michael J. Lippincott, Kenneth I. Brewer, Vince Rubinetti, Faisal Alquaddoomi, Gregory P. Way

    In Review at Patterns: bioRxiv

  • Progress and new challenges in image-based profiling

    Erik Serrano, John Peters, Jesko Wagner, Rebecca E. Graham, Zhenghao Chen, Brian Feng, Gisele Miranda, Alexandr A. Kalinin, Loan Vulliard, Jenna Tomkinson, Cameron Mattson, Michael J. Lippincott, Ziqi Kang, Divya Sitani, Dave Bunten, Srijit Seal, Neil O. Carragher, Anne E. Carpenter, Shantanu Singh, Paula A. Marin Zapata, Juan C. Caicedo, Gregory P. Way

    Available at: arXiv

  • A quadratic paradigm describes the relationship between phenotype severity and variation

    Abigail Mumme-Monheit, Grace E. Gustafson, Colette A. Hopkins, Raisa Bailon-Zambrano, Juliana Sucharov, Michael J. Lippincott, Gregory P. Way, Kathryn L. Colborn & James T. Nichols

    Available at: Nature Communications

  • A morphology and secretome map of pyroptosis

    Lippincott MJ, Jenna Tomkinson, Dave Bunten, Milad Mohammadi, Johanna Kastl, Johannes Knop, Ralf Schwandner, Jiamin Huang, Grant Ongo, Nathaniel Robichaud, Milad Dagher, Masafumi Tsuboi, Carla Basualto-Alarcón, Gregory P. Way

    Available at: MBoC

  • Protein prediction models support widespread post-transcriptional regulation of protein abundance by interacting partners.

    Srivastava H, Lippincott MJ, Currie J, Canfield R, Lam MPY, et al. (2022)

    PLOS Computational Biology: PLOS Computation Biology

  • Genetic and Epigenetic Inheritance at Telomeres.

    Lister-Shimauchi EH, McCarthy B, Lippincott MJ, Ahmed S.

    Epigenomes: Epigenomes

Scientific Appointments

  • 2024 – Present

    Wellbeing and Engagement Committee

    Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO

  • 2023 – Present

    Cell Biology Graduate Teaching Assistant

    University of Colorado Anschutz Medical Campus, Aurora, CO

  • 2023 – Present

    Volunteer

    Clear Directions Mentoring, Aurora, CO

  • 2023 – 2025

    Journal Club Committee

    Cell Biology, Stem Cells, and Development, University of Colorado Anschutz Medical Campus, Aurora, CO

  • 2021 – 2022

    Undergraduate Research Mentor

    University of North Carolina at Chapel Hill, Chapel Hill, NC

  • 2020 – 2022

    Research Mentor for Undergraduates

    Maryville University, Saint Louis, MO

  • 2019 – 2021

    Teaching Aid – Chemistry/Cell Biology

    Maryville University, Saint Louis, MO

  • 2019 – 2021

    Lab technician training manager

    Maryville University, Saint Louis, MO

  • 2017 – 2019

    Biology and Maths Tutor

    Maryville University, Saint Louis, MO

Presentations

  • Society of Biomolecular Imaging and Informatics, Talk
    October 27, 2025, Boston, MA

  • Cell Biology, Stem Cells, and Development Retreat, Talk
    Oct. 24, 2025, Estes Park, CO

  • Reproducible Computational methods course - Guest Lecturer
    Oct. 17, 2025

  • Leveraging AI in Cell Biology, Invited speaker
    Apr. 10, 2025, Saint Louis, MO

  • Systems applications for cancer biology, Poster
    Feb 10, 2025, Aurora, CO

  • Reproducible Computational methods course - Guest Lecturer
    Nov. 15, 2024, Aurora, CO

  • American Society for Cell Biology Cell Bio conference, Talk
    Dec. 3, 2024, San Diego, CA

  • Cell Biology, Stem Cells, and Development Retreat, Poster
    Oct. 18, 2024, Breckinridge, CO

  • Center for Health Artificial Intelligence Retreat, Poster
    Aug. 27, 2024, Denver, CO

  • Computational Systems for Integrative Genomics, Talk
    Jul. 18, 2024, New York, NY

  • American Society for Cell Biology Cell Bio conference, Poster
    Dec. 3, 2023, Boston, MA

  • Center for Health Artificial Intelligence Retreat, Talk
    Aug. 19, 2023, Aurora, CO

  • Cell Biology, Stem Cells, and Development Retreat, Poster
    Oct. 13, 2023, Breckinridge, CO

Languages